Research Scholar, Bharathiar School of Management & Entrepreneur Development, Bharathiar University, Coimbatore
Abstract
In a continuing effort to develop novel Benzimidazole
endowed with better pharmacological profiles. A series of Benzimidazole
derivatives were designed on the basis of previously developed QSARs.
These drugs offer novel mechanisms of action and expanded spectrums
of activity over traditional treatment option. However, with these new
agents comes the need for increased awareness of the potential
interactions and toxicities associated with these drugs. The best models
for different antibacterial agents against Escherichia coli were first
validated by leave-one-out cross validation procedure. It was revealed
that topological, physicochemical and indicator parameters were found
to have overall significant correlationship with antibacterial activity
against Escherichia coli and these studies provide an insight to design
new molecules.
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References
Hanch, C., Leo, A., Hoekman, D.H., Exploring QSAR, Fundamentals and application in chemistry and biology., American Chemical Society., Washington, DC, USA, (1995).
Hanch, C., Leo, A., Hoekman, D.H., Exploring QSAR, Hydrophobic, Electronic and Steric Constants., American Chemical Society., Washington, DC, USA, (1995).
Goker, H., Alp, H., Synthesis and potent antimicrobial activity of some novel carboxamidines., Molecules., 10 (2000) 1377-1386.
Melagraki, G., Afantitis., QSAR study on para substituted aromatic sulfonamides as carbonic anhydrase II inhibitors using topological information indices., Bioorg. Med. Chem., 14 (2006) 1108-1114.
Delgado, D. N., In Wilson and Gisvold’s Textbook of Medicinal and Pharmaceutical chemistry, 10th ed.; LippincottRavon: New York, (1998) 173.
Boiani, M., Imidazole and benzimidazole derivatives as chemotherapeutic agents., J. Med. Chem., 5 (2005) 409-424.
Campbell, W.C., Benzimidazole: Veterinary uses. Parasitol. Today., 6 (1990) 130- 133.
Ayhan-Kilcigil., G., Altanlar, N., Synthesis and antifungal properties of some benzimidazole derivatives., Turk. J. Chem., 30 (2006) 223-228.
Kus, C., Synthesis and antioxidant properties of some novel benzimidazole derivatives on lipid peroxidation in the rat liver., Arch. Pharm. Res., 27(2004) 156-163.
Zulu, I., Veitch, A., Albendazole chemotherapy for AIDS related diarrhea in zambia clinical, parasitological and mucosal response., Alim. Pharmacol. Ther., 16 (2002) 595-601.
Kazimierczuk, Z, Upcroft, J.A., Synthesis, antiprotozoal and antibacterial activity of nitro and halogeno substituted benzimidazole derivative., Acta Biochim. Polon., 49-1 (2002) 185-195.
Didier, E.S., Stovall, M.E., Green, L.C., Brindley, P.J., Sestak, K., Didier, P.J., Epidemiology of microsporidiosis sources and modes of transmission., Vet. Parasitol., 126 (2004) 145-166.
Podunavac, S.O.,Quantitative Structure activity relationships to predict antibacterial effect of some benzimidazole derivatives., APTEFF. , 39 (2008) 181-191.
Podunavac-Kuzmanovic, S.O., Cvetkovic, D.D., Biological activity of zinc (II) and nickel (II) complexes with some 2-aminobenzimidazole derivatives in microorganisms of environmental relevance synthesis., Centr. Eur. J.
Occupat. Environ. Med., 10(2006)55-60.
Perisic,-Janjie, N.U., Podunavac-Kuzmanovic, S.O., Balaz, J.S., Vlaovic, D., Chromatographic behaviour and lipophilicity of some benzimidazole derivatives .,J. Planar. Chromatogr., 13(2000)123-129.
Podunavac-Kuzmanovic, S.O., Leovac, V.M., Perisic,-Janjie, N.U., Rogan, J., Balaz, J., Complexes cobalt (II), Zinc
(II), Copper (II) with some newly synthesized benzimidazole derivatives and their antibacterial activity., J. Serb. Chem. Soc., 64(1999)381-388.
Podunavac-Kuzmanovic, S.O., Markov, S.L., Antimicrobial activity of Copper (II) complexes with some benzimidazole derivatives against microorganism widely distributed in the environment ., Centr. Eur. J. Occupat.
Environ. Med., 12(2006)61- 66.
Podunavac-Kuzmanovic, S.O., Cvetkovic, D.D., Antibacterial evalution of some benzimidazole derivatives and
their zinc (II) complexes., J. Serb. Chem. Soc., 75(2007)459-466.
Podunavac-Kuzmanovic, S.O., Markov, S.L., Barna, D.J., Relationship between the lipophilicity and antifungal
activity of some benzimidazole derivative., J. Theor. Comp. Chem., 6(2007)687-698.
Podunavac-Kuzmanovic, S.O., Cvetkovic, D.D., Anion effect on antimicrobial activity of metal complexes with
benzimidazole derivative., CICEQ., 13(2007)68-71.
Perisic,-Janjie, N.U., Podunavac-Kuzmanovic, S.O., RPTLC study of QSRR and QSAR for some benzimidazole derivatives., J. Planar. Chromatography., 21(2008)135-141.
Topliss, J.G., Edwards, R.P., Chance factors in studies of quantitative structure activity relationships., J. Med.
Chem.,22 (1979)1238-1244.
Snedecor, G.W., Cochran, Statistical Methods ., Oxford and IBH., New Delhi., India., (1967) 381.
Chaltterjee, S., Hadi, A.S., Price, B., Regression Analysis by examples., wiley VCH., New York., USA.,2000.
Diudea, M.V., QSPR/QSAR studies for molecular descriptors., Nova Science ., Huntington , New York., USA., 2000.
Golbraikh, A., Tropsha, J., Beware of q2., J. Mol. Graph. Mod., 20(2002)269-276.
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